THE ROLES OF CARDIOVASCULAR DISEASE AND DEPRESSION IN THE RELATIONSHIP BETWEEN RESPIRATORY DISEASE AND NEUROPSYCHOLOGICAL FUNCTIONING IN OLDER ADULTS

The pathophysiology of severe respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), supports the theory that oxygen deprivation to the brain may impact the brain’s execution of cognitive functions. Imaging studies also suggest that neuroanatomical changes in areas of the brain responsible for cognitive processes may be associated with respiratory diseases. Research in this area has failed to conclude definitively, especially in an older adult population, which is more likely to experience comorbid depression and cardiovascular disease, universally acknowledged predictors of poorer cognitive performance, the extent of the relationship between respiratory illness and cognitive functioning. The current study investigated the association between respiratory disease with cognitive performance in older adults, also considering the relative impact of cardiovascular disease and depression. Functioning was examined globally and in the individual domains of psychomotor functioning and verbal ability. Physiological measures of disease were also explored for potential relationships with cognition. Results suggest that depression was consistently associated with poorer performance across cognitive domains, whereas cardiovascular disease was primarily associated with reduced functioning in psychomotor tasks. After accounting for these effects, no additional association between respiratory disease and cognitive functioning was identified, with the possible exception of COPD relating to enhanced verbal ability. None of the physiological measures obtained were found to correlate with cognition in this research. Explanations and implications of these findings are discussed

More on the Narrowing of Impact Broadened Radio Recombination Lines at High Principal Quantum Number

Recently Alexander and Gulyaev have suggested that the apparent decrease in impact broadening of radio recombination lines seen at high principal quantum number n may be a product of the data reduction process, possibly resulting from the presence of noise on the telescope spectra that is not present on the calculated comparison spectra. This is an interesting proposal. However, there are serious problems with their analysis that need to be pointed out. Perhaps the most important of these is the fact that for principal quantum numbers below n = 200, where the widths are not in question, their processed generated profile widths do not fit the widths of the processed lines obtained at the telescope. After processing, the halfwidths of the generated and telescope profiles must agree below n = 200 if we are to believe that the processed generated linewidths above n = 200 are meaningful. Theirs do not. Furthermore, we find that after applying the linewidth reduction factors found by Alexander and Gulyaev for their noise added profiles to our generated profiles to simulate their noise adding effect, the processed widths we obtain still do not come close to explaining the narrowing seen in the telescope lines for n values in the range 200 < n < 250. It is concluded that what is needed to solve this mystery is a completely new approach using a different observing technique instead of simply a further manipulation of the frequency-switched data.Comment: Six pages with 4 figures. Accepted for publication in Astrophysics and Space Scienc

An optical Fourier transform coprocessor with direct phase determination.

The Fourier transform is a ubiquitous mathematical operation which arises naturally in optics. We propose and demonstrate a practical method to optically evaluate a complex-to-complex discrete Fourier transform. By implementing the Fourier transform optically we can overcome the limiting O(nlogn) complexity of fast Fourier transform algorithms. Efficiently extracting the phase from the well-known optical Fourier transform is challenging. By appropriately decomposing the input and exploiting symmetries of the Fourier transform we are able to determine the phase directly from straightforward intensity measurements, creating an optical Fourier transform with O(n) apparent complexity. Performing larger optical Fourier transforms requires higher resolution spatial light modulators, but the execution time remains unchanged. This method could unlock the potential of the optical Fourier transform to permit 2D complex-to-complex discrete Fourier transforms with a performance that is currently untenable, with applications across information processing and computational physics

The Journal of the Friends' Historical Society vol. 2 No. 2

1. Notices. 2. Notes and Queries. 3. Remarks on the Letter in Cypher from F. Howgill to George Fox. 4. Joseph Williams's Recollections of the Irish Rebellion of 1798 II. 5. The Settlement of London Yearly Meeting. 6. Robert Smith and William Dewsbury. 7. Joseph Rule, the Quaker in White. 8. Early Friends and the Use of Tobacco. 9. George Fox in the Dictionary of National Biography. 10. Prize Essays on the causes of the decline of the Society of Friends. 11. Nicholas Waln to Arthur Howell. 12. Meeting in Yorkshire 1668 II. 13. Wheat for William Penn. 14. Friends in Current Literature. 15. Friends' Reference Library, Devonshire House. 16. Fifth List of Members. 17. Editorial Forecast

Hydrological and associated biogeochemical consequences of rapid global warming during the Paleocene-Eocene Thermal Maximum

The Paleocene-Eocene Thermal Maximum (PETM) hyperthermal, ~ 56 million years ago (Ma), is the most dramatic example of abrupt Cenozoic global warming. During the PETM surface temperatures increased between 5 and 9 °C and the onset likely took < 20 kyr. The PETM provides a case study of the impacts of rapid global warming on the Earth system, including both hydrological and associated biogeochemical feedbacks, and proxy data from the PETM can provide constraints on changes in warm climate hydrology simulated by general circulation models (GCMs). In this paper, we provide a critical review of biological and geochemical signatures interpreted as direct or indirect indicators of hydrological change at the PETM, explore the importance of adopting multi-proxy approaches, and present a preliminary model-data comparison. Hydrological records complement those of temperature and indicate that the climatic response at the PETM was complex, with significant regional and temporal variability. This is further illustrated by the biogeochemical consequences of inferred changes in hydrology and, in fact, changes in precipitation and the biogeochemical consequences are often conflated in geochemical signatures. There is also strong evidence in many regions for changes in the episodic and/or intra-annual distribution of precipitation that has not widely been considered when comparing proxy data to GCM output. Crucially, GCM simulations indicate that the response of the hydrological cycle to the PETM was heterogeneous – some regions are associated with increased precipitation – evaporation (P – E), whilst others are characterised by a decrease. Interestingly, the majority of proxy data come from the regions where GCMs predict an increase in PETM precipitation. We propose that comparison of hydrological proxies to GCM output can be an important test of model skill, but this will be enhanced by further data from regions of model-simulated aridity and simulation of extreme precipitation events

The valuation of European financial firms

We extend the recent literature concerning accounting based valuation models to investigate financial firms from six European countries with substantial financial sectors: France, Germany, Italy, Netherlands, Switzerland and the UK. Not only are these crucial industries worthy of study in their own right, but unusual accounting practices, and inter-country differences in those accounting practices, provide valuable insights into the accounting-value relationship. Our sample consists of 7,714 financial firm/years observations from 1,140 companies drawn from 1989-2000. Sub-samples include 1,309 firm/years for banks, 650 for insurance companies, 1,705 for real estate firms, and 3,239 for investment companies. In most countries we find that the valuation models work as well or better in explaining cross-sectional variations in the market-to-book ratio for financial firms as they do for industrial and commercial firms in the same countries, although Switzerland is an exception to this generalization. As expected, the results are sensitive to industrial differences, accounting regulation and accounting practices. In particular, marking assets to market value reduces the relevance of earnings figures and increases that of equity